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How CBD and Ketamine Work Together as an Anti-Depressant

Jan 25, 2022 3:08:20 PM

How CBD and Ketamine work together as an anti-depressant  - Featured Image - NeuroMend

New study shows that administering both CBD and Ketamine together can work as an anti-depressant.

Depression on the Rise

According to the World Health Organization, by 2030, depression will be the leading cause of disability worldwide. With depression on the rise, we look to new studies for our fight against anxiety and depression.

More recently, the United States, slowly but surely, is accepting the potential for both cannabis and ketamine to treat profound ailments of depression.

Ketamine for Depression

The FDA recently added esketamine, a ketamine-like medication, as a prescribed treatment for depression. All over the US, clinics are offering ketamine treatments to patients. Ketamine's side effects, including “hyperlocomotion", can make it difficult to do much else when being treated with ketamine.

But what if you could minimize the adverse effects while preserving the therapeutic value?

Find out if your insurance company covers Ketamine Treatments.

How CBD and Ketamine work together as an anti-depressant  | Silverseed

CBD and Ketamine

Cannabidiol (CBD) and ketamine both work through the endocannabinoid system, but what impact does combining them have?

Cannabidiol (CBD) is a non-psychostimulant compound from Cannabis sativa, which has shown anti-depressant effects without inducing hyperlocomotion. According to a recently published study, mixing cannabidiol, or CBD, with ketamine, makes it possible to receive the therapeutic value from ketamine without inducing its psychotomimetic effects.

See full results here.

CBD activates the AMPA receptors, similarly to ketamine, producing an anti-depressant-like effect. The cannabidiol not only prevents the hyperlocomotion caused by ketamine, but it does so without affecting its anti-depressant efficacy.

By administering ketamine and CBD to mice, both alone and in combination, the results from the study suggest that combining CBD and ketamine can be a valuable therapeutic approach for eliciting a desirable anti-depressant effect while possibly avoiding some of the side effects.

Are you a medicinal smoker? See here for the best options for life insurance for people who use marijuana medicinally.


At NeuroMend, we specialize in treating behavioral health disorders and chronic pain, usually among patients who have treatment-resistant conditions. Studies have demonstrated that Ketamine infusion therapy can work more effectively and safely than many conventional treatments and medications.

Ketamine can treat and alleviate mood disorders (mood boosters) such as depression and anxiety, chronic pain disorders, and can reduce inflammation.


Are you looking for effective treatment solutions? Contact us for more information about our offerings or schedule a free consultation with us.

Disclaimer: As of September 29, 2023, NeuroMend no longer offers Spravato treatments. We apologize for any inconvenience and encourage you to consult with our team or your healthcare provider for alternative options.

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Neuromend Team

Written by Neuromend Team

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